Disorders - Depressive Disorders
Brown, C. H., Brincks, A., Huang, S., Perrino, T., Cruden, G., Pantin, H., Howe, G., Young, J. F., Beardslee, W., Montag, S., Sandler, I.
This paper presents the first findings of an integrative data analysis of individual-level data from 19 adolescent depression prevention trials (n=5210) involving nine distinct interventions across 2 years post-randomization. In separate papers, several interventions have been found to decrease the risk of depressive disorders or elevated depressive/internalizing symptoms among youth. One type of intervention specifically targets youth without a depressive disorder who are at risk due to elevated depressive symptoms and/or having a parent with a depressive disorder. A second type of intervention targets two broad domains: prevention of problem behaviors, which we define as drug use/abuse, sexual risk behaviors, conduct disorder, or other externalizing problems, and general mental health. Most of these latter interventions improve parenting or family factors. We examined the shared and unique effects of these interventions by level of baseline youth depressive symptoms, sociodemographic characteristics of the youth (age, sex, parent education, and family income), type of intervention, and mode of intervention delivery to the youth, parent(s), or both. We harmonized eight different measures of depression utilized across these trials and used growth models to evaluate intervention impact over 2 years. We found a significant overall effect of these interventions on reducing depressive symptoms over 2 years and a stronger impact among those interventions that targeted depression specifically rather than problem behaviors or general mental health, especially when baseline symptoms were high. Implications for improving population-level impact are discussed.
Prevention Science, 19(Supplement 1) : 74-94
- Year: 2018
- Problem: Depressive Disorders
- Type: Systematic reviews
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Stage: Universal prevention
, At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions (any)
Lowden, A., Ozturk, G., Moreno, C.
Objectives/Introduction: Sleep complaints and lowered mood states are frequently reported in adolescence, November was marked as the worst month for mood and fatigue in a previous questionnaire study. The aim of this study was to treat depressive symptoms by use of light goggles during the Scandinavian dark winter period. Method(s): In an intervention study, high school students (15- 20 years; 52% boys) answered a question on willingness to try light goggles (Luminette) in the morning to improve health. For 2 weeks 60 invited students with moderate or high depression scores on the depression scale (HAD-D6) wore glasses during 20 min in the morning before going to school and at weekends. Subjects were randomized to either a white light condition (=1,000 lux) or red light condition. Subjects were questioned before and after treatment and a repeated mixed model analysis was performed using condition (before/ after) and light (white/red) as factors. Result(s): Compliance to treatment was very good according to daily logs. In total 50 students fulfilled the protocol. Effects of white and red light did not yield significant differences. General improvement on the depression scale (HAD-D6) was 26% (p < 0.001) 7.3% on the Epworth Sleepiness Scale (p < 0.006), insomnia index 16% (Karolinska Sleep Questionnaire, p < 0.013) and increased morningness (Diurnal Type Scale) 5.5%. After treatment 42% of the students would recommend use of light goggles to peers and 37% would partly do so 2% disagreed with goggle use. The lack of difference between white and red diods might be explained by placebo induced effects or by the strength of direct lighting effects on pathways signaling to mood regulating brain areas. Conclusion(s): The study demonstrated that at a season were very little daylight is obtained traveling to school, use of goggles reduces symptoms of depression and has mild positive effects on insomnia symptoms, daytime sleepiness and promotes morningness.
Journal of Sleep Research, 27 (Supplement 1) : 347-348
- Year: 2018
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Complementary & Alternative Interventions (CAM)
, Bright light therapy
Ajilchi, B., Kisely, S., Nejati, V., Frederickson, J.
Background: Social cognition is commonly affected in psychiatric disorders and is a determinant of quality of life. However, there are few studies of treatment. Objective: To investigate the efficacy of intensive short-term dynamic psychotherapy on social cognition in major depression. Method: This study used a parallel group randomized control design to compare pre-test and post-test social cognition scores between depressed participants receiving ISTDP and those allocated to a wait-list control group. Participants were adults (19-40 years of age) who were diagnosed with depression. We recruited 32 individuals, with 16 participants allocated to the ISTDP and control groups, respectively. Both groups were similar in terms of age, sex and educational level. Results: Multivariate analysis of variance (MANOVA) demonstrated that the intervention was effective in terms of the total score of social cognition: the experimental group had a significant increase in the post-test compared to the control group. In addition, the experimental group showed a significant reduction in the negative subjective score compared to the control group as well as an improvement in response to positive neutral and negative states. Conclusion: Depressed patients receiving ISTDP show a significant improvement in social cognition post treatment compared to a wait-list control group. Copyright © 2018 Informa UK Limited, trading as Taylor & Francis Group
Journal of Mental Health, : 1-5
- Year: 2018
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Psychological Interventions (any)
, Other Psychological Interventions
Atkinson, S., Lubaczewski, S., Ramaker, S., England, R. D., Wajsbrot, D. B., Abbas, R., Findling, R. L.
Objective: To evaluate the short-term efficacy and safety of desvenlafaxine versus placebo in the treatment of children and adolescents with major depressive disorder (MDD). Methods: Outpatient children (7-11 years) and adolescents (12-17 years) who met DSM-IV-TR criteria for MDD and had screening and baseline Children's Depression Rating Scale-Revised (CDRS-R) total scores >40 were randomly assigned to 8 weeks of treatment with placebo, low exposure desvenlafaxine (20, 30, or 35 mg/day based on baseline weight), or higher exposure desvenlafaxine (25, 35, or 50 mg/day based on baseline weight). The primary efficacy endpoint was change from baseline in CDRS-R total score at week 8, analyzed using a mixed-effects model for repeated measures. Secondary efficacy assessments included Clinical Global Impressions-Severity and Clinical Global Impressions-Improvement scales. Safety assessments included adverse events and the Columbia-Suicide Severity Rating Scale. Results: The safety population included 363 patients (children, n = 109; adolescents, n = 254). No statistical separation from placebo was observed for either desvenlafaxine group for CDRS-R total score or for any secondary efficacy endpoint. At week 8, adjusted mean (standard error) changes from baseline in CDRS-R total score for the desvenlafaxine low exposure, desvenlafaxine high exposure, and placebo groups were -23.7 (1.1), -24.4 (1.1), and -22.9 (1.1), respectively. The incidence of adverse events was similar among groups. Conclusion: Low and high exposure desvenlafaxine groups did not demonstrate efficacy for the treatment of MDD in children and adolescents in this double-blind, placebo-controlled trial. Desvenlafaxine (20-50 mg/day) was generally safe and well tolerated with no new safety signals identified in pediatric patients with MDD in this study. Copyright © Sarah Atkinson et al. 2017; Published by Mary Ann Liebert, Inc.
Journal of Child and Adolescent Psychopharmacology, 28(1) : 55-65
- Year: 2018
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Biological Interventions (any)
, Serotonin-norepinephrine reuptake inhibitors (SNRIs), Antidepressants (any)
Bevan-Jones, R., Stone, Z., Thapar, A., Jones, I., Smith, D., Simpson, S.
Background: Adolescent depression is common and leads to distress and impairment for individuals/families. Treatment/prevention guidelines stress the need for good information and evidence-based psychosocial interventions. There has been growing interest in psychoeducational interventions (PIs), which broadly deliver accurate information about health issues and self-management. Objective, methods: Systematic search of targeted PIs as part of prevention/management approaches for adolescent depression. Searches were undertaken independently in PubMed, PsycINFO, EMBASE, guidelines, reviews (including Cochrane), and reference lists. Key authors were contacted. No restrictions regarding publishing dates. Results: Fifteen studies were included: seven targeted adolescents with depression/depressive symptoms, eight targeted adolescents 'at risk' e.g. with a family history of depression. Most involved family/group programmes; others included individual, school-based and online approaches. PIs may affect understanding of depression, identification of symptoms, communication, engagement, and mental health outcomes. Conclusion, practice implications: PIs can have a role in preventing/managing adolescent depression, as a first-line or adjunctive approach. The limited number of studies, heterogeneity in formats and evaluation, and inconsistent approach to defining PI, make it difficult to compare programmes and measure overall effectiveness. Further work needs to establish an agreed definition of PI, develop/evaluate PIs in line with frameworks for complex interventions, and analyse their active components. Copyright © 2017 The Authors
Patient Education and Counseling, 101(5) : 804-816
- Year: 2018
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
, Disorder established (diagnosed disorder)
-
Treatment and intervention: Psychological Interventions (any)
, Psychoeducation
Bowers, B., Flory, R., Ametepe, J., Staley, L., Patrick, A., Carrington, H.
This study evaluated the effectiveness of 30 or 60 min of daily exposure to high-density or to zero-density (placebo condition) negative air ions over 18 days on the symptoms of seasonal affective disorder (SAD) in 40 participants under controlled laboratory conditions. Exposure to high-density negative air ions was superior to zero-density negative air ions in alleviating depression and the atypical symptoms of SAD. Also, more subjects in the high-density negative air ions groups met two different clinical response criteria than did those in the zero-density groups. Within the high density treatment group, both the short and long daily exposure reduced SAD symptoms. Exposure to negative air ions produced no negative side effects, and no ozone was produced by the ion generators. In both the high-density negative air ions and zero-density negative air ions groups, a significant placebo effect was found for most clinical measures. Finally, for the high-density negative air ion groups, subjects with a morningness chronotype responded better to treatment with high-density negative air ions than did those with an eveningness chronotype. Copyright © 2017 Elsevier B.V.
Psychiatry Research, 259 : 7-14
- Year: 2018
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Complementary & Alternative Interventions (CAM)
, Other complementary & alternative interventions
Kim, S., Kim, H., Lee, H., Noh, D.
PURPOSE: This study aimed to examine the effects of a brief stress management intervention on depression, anxiety, suicidal ideation, and aggression among Korean male college students.
DESIGN AND METHODS: In a repeated measures design, participants were assessed before, immediately after, and 3 months after the intervention. Data of 40 experimental and 32 control participants were analyzed using linear mixed models.
FINDINGS: There were significant time-by-group interaction effects for depression and trait anxiety, but not for state anxiety, suicidal ideation, and aggression.
PRACTICE IMPLICATIONS: The intervention has long-term effects for depression and trait anxiety. Future research should involve a randomized controlled trial on a larger scale.
Perspectives in Psychiatric Care, 54(1) : 88-94
- Year: 2018
- Problem: Anxiety Disorders (any), Depressive Disorders, Suicide or self-harm behaviours (excluding non-suicidal self-harm)
- Type: Controlled clinical trials
-
Stage: Universal prevention
-
Treatment and intervention: Psychological Interventions (any)
, Other Psychological Interventions
Wang, Z., Chen, C.
At present, the probability of criminal cases in our country is on the rise, which has a great relationship with the lack of mental health intervention. Therefore, the use of ideological and political education for students' mental health intervention and evaluation was proposed. In this paper, the concept and function of mental health education and ideological and political education were expounded in detail, and then a two-month experiment on ideological and political education was carried out in 2016 freshmen of S University. Experiments were carried out by using experiments such as Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), Self-Rated Health Measurement Scale (SRHMS), mini version international psychiatric interview (M.I.N.I), Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS) and Irrational Beliefs Scale (IBS). Before and after the intervention of SDS, the total score of intervention group were significantly different from control group (t=3.84, P<0.05; t=-3.26, P<0.05). Before and after the intervention of IBS, there was no significant difference between the total score of the intervention group and the control group. (t=1.86, P>0.05; t=0.20, P>0.05). The intervention of Ideological and political education has an effect on students' depression. Copyright © 2018, Scientific Publishers of India. All rights reserved.
Biomedical Research (India), 29(6) : 1244-1249
- Year: 2018
- Problem: Depressive Disorders
- Type: Controlled clinical trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions (any)
, Other Psychological Interventions
Zainaldeen, M. H., Hasan, N. E., Ahmed-Ali, F. A. H., Altahoo, H. S., Rashid-Doubell, F., Fredericks, S.
Juggling-exposure therapy has been employed in the management of anxiety and post-traumatic stress disorder. However, there is little evidence of the effectiveness of juggling-exposure in improving emotional states in subclinical conditions. This study aimed at evaluating the effect of a course of juggling on emotional states, sleep quality and blood pressure among medical students at a critical stage of their academic training. Blood pressure, psychometric and quality of sleep assessments were performed pre- and post-examination period for two groups of students: juggling-exposed (n = 9) and non-juggling-exposed (n = 11). Juggling exposure consisted of practice-drills for one hour per week during the period spanning the student's scheduled exams. Comparisons were made between quantitative measures that were collected pre- and post-the course of juggling drills. Differences in scores and measures were expressed as percentage-change and compared between non-juggling and juggling groups. Overall, there was a decrease in depression and anxiety scores between the pre-to post-exam periods. This decrease was statistically significant for both non-juggling and juggling groups with respect to anxiety, but only the juggling-exposed group had a significant reduction regarding depression scores. However, when calculated as percentage-change over the pre-to post-exam period, there was no significant difference in any of the parameters for either of the two groups. Practicing juggling drills had an influence on emotional states.
Complementary Therapies in Clinical Practice, 30 : 64-67
- Year: 2018
- Problem: Depressive Disorders
- Type: Controlled clinical trials
-
Stage: Universal prevention
-
Treatment and intervention: Complementary & Alternative Interventions (CAM)
, Other complementary & alternative interventions
Caldwell, Y. T., Steffen, P. R.
Heart rate variability (HRV) is a significant marker of health outcomes with decreased HRV predicting increased disease risk. HRV is decreased in major depressive disorder (MDD) but existing treatments for depression do not return heart rate variability to normal levels even with successful treatment of depression. Heart rate variability biofeedback (HRVB) increases heart rate variability but no studies to date have examined whether combining HRVB with psychotherapy improves outcome in MDD treatment. The present study used a randomized controlled design to compare the effects of HRVB combined with psychotherapy on MDD relative to a psychotherapy treatment as usual group and to a non-depressed control group. The HRVB + psychotherapy group showed a larger increase in HRV and a larger decrease in depressive symptoms relative to the other groups over a six-week period, whereas the psychotherapy group only did not improve HRV. Results support the supplementation of psychotherapy with HRVB in the treatment of MDD. (PsycINFO Database Record (c) 2018 APA, all rights reserved)
International Journal of Psychophysiology, 131 : 96-101
- Year: 2018
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Psychological Interventions (any)
, Biofeedback, neurofeedback, audio/video feedback
Chen, C. Y.
Objectives: To explore the intervention effect of group intervention on depression of urban college students and explore the methods of group training in colleges and universities. Methods: In the study, 40 students with depression were selected as subjects, and they were divided into observation group and control group randomly. 49D cognitive coping group training and psychological intervention were carried out for the students in the observation group, and the normal training was taken in the control group. The intervention effects of three kinds of measuring tools, SDS, ASQ and SCSQ were compared to 7d college students before and after intervention. After six months, the SDS self-assessment scale was used to measure the return visit. Results: There was no significant difference in depression score between the observation group and the control group before intervention (p > 0.05). Conclusions: Group intervention on depression of urban college students can obviously improve their depression and promote their mental health. Therefore, it should be actively carried out.
Basic and Clinical Pharmacology and Toxicology, 122 (Supplement 2) : 17-18
- Year: 2018
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Psychological Interventions (any)
, Other Psychological Interventions
De-Voogd, L., Wiers, R. W., De-Jong, P. J., Zwitser, R. J., Salemink, E.
Introduction Negatively biased interpretations play an important role in anxiety and depression, which are highly prevalent in adolescence, and changing such biases might thus reduce or prevent emotional disorders. We investigated the short- and long-term effects of an online interpretation bias modification training in unselected adolescents to explore its potential in preventing anxiety and depression. Methods Participants (N = 173) were randomly allocated to eight online sessions of interpretation or placebo training. Interpretation bias was assessed pre- and post-training. Primary outcomes of anxiety and depression, and secondary measures of emotional resilience were assessed pre- and post-training and at three, six, and twelve months follow-up. Results Compared to placebo, interpretation training marginally increased positive interpretations. Irrespective of training condition, symptoms of anxiety and depression showed a decline post-training and at follow-up, and indices of resilience showed an increase. Change in interpretation bias, baseline interpretation bias, stressful life events, or number of training sessions completed did not moderate the effects on anxiety or depression. Conclusions Results suggest that interpretation training as implemented in this study has no added value in reducing symptoms or enhancing resilience in unselected adolescents. Copyright © 2018 de Voogd et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PLoS ONE, 13 (3) (no pagination)(e0194274) :
- Year: 2018
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Universal prevention
-
Treatment and intervention: Service Delivery & Improvement, Psychological Interventions (any)
, Attention/cognitive bias modification
, Technology, interventions delivered using technology (e.g. online, SMS)